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What mucinex is safe for high blood pressure? Yes, it's fine for you to take Mucinex DM if you have high blood pressure. It contains two active ingredients: dextromethorphan and guaifenesin. Dextromethorphan is a cough suppressant. What is the first line medication for hypertension? thiazide-type diuretics Does mucinex interfere with blood pressure? A: Mucinex D contains pseudoephedrine which can increase your blood pressure, cause anxiety, sleep problems and have other side effects. What makes your blood pressure go up and down? Caffeine may boost your blood pressure, while alcohol lowers it. These substances can also increase your risk for diseases that increase your risk for high blood pressure, such as heart disease and kidney disease.
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